CTN NEWS – Asthma development is more likely in children whose father was exposed to second-hand smoke as a child, according to a new study.
Led by University of Melbourne researchers Jiacheng Liu and Dr. Dinh Bui, the study also shows that children’s risk of asthma is even higher if their father was exposed to second-hand smoke and went on to become a smoker.
The study was based on Tasmanian Longitudinal Health Study
The study was based on Asthma data from the Tasmanian Longitudinal Health Study (TAHS), led by University of Melbourne Professor Shyamali Dharmage.
One of the world’s largest and longest ongoing respiratory studies, having commenced in 1968. For this study, researchers looked at 1689 children who grew up in Tasmania, their fathers, and their paternal grandparents.
The team compared data on whether the children had developed asthma by the age of seven years with data on whether the fathers grew up with parents who smoked when they were under the age of 15. They also included data on whether the fathers were current or former smokers.
Risk of non-allergic asthma in children
We found that the risk of non-allergic asthma in children increases by 59% if their fathers were exposed to second-hand smoke in childhood, compared to children whose fathers were not exposed, Liu said. The risk was even higher, at 72%, if the fathers were exposed to second-hand smoke and went on to smoke themselves.
Bui said the findings show how the damage caused by smoking can have an impact not only on smokers but also on their children and grandchildren — though the risk can be lowered in their grandchildren if their children avoid smoking.
Researchers can’t be certain of how this damage is passed
And while the researchers can’t be certain of how this damage is passed on through generations, Dharmage said they think it may be to do with epigenetic changes.
This is where factors in our environment, such as tobacco smoke, interact with our genes to modify their expression. These changes can be inherited but may be partially reversible for each generation, he said.
It’s possible that tobacco smoke is creating epigenetic changes in the cells that will go on to produce sperm when boys grow up. These changes can then be passed on to their children.”
The researchers will now investigate if the increased risk of asthma persists into adult life and whether fathers who were exposed to second-hand smoke as children pass on any increase in allergies or other lung diseases to their children.
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