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Breast Cancer Detection With Low-Dose Positron Emission Mammography

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Breast Cancer Detection With Low-Dose Positron Emission Mammography

(CTN News) – Using low-dose positron emission mammography (PEM), invasive breast cancer can be detected, according to a study published online Feb. 9 in Radiology: Imaging Cancer.

A study conducted by Vivianne Freitas, M.D., and colleagues from the University of Toronto examined the feasibility of using low-dose PEM concurrently with magnetic resonance imaging (MRI) in the detection of breast cancer.

It was the purpose of this study to examine the effects of low doses of fluorodeoxyglucose (18F-FDG) administered to 25 female participants newly diagnosed with breast cancer, who were treated with fluorine-18-labeled fluorodeoxy glucose.

A review of the PEM images taken one and four hours after the injection of 18F-FDG was conducted by two breast radiologists who were not aware of the location where the breast cancer had been found at the time.

It was found that 24 of 25 cancers were detected by PEM using 100 sets of bilateral images; the performance was comparable even after three hours of radiotracer uptake. There was a median diameter of 31 mm for invasive breast cancer.

During PEM, three additional lesions of grade 2 in situ were missed. While the difference between PEM and MRI was not statistically significant (16 versus 62 percent), PEM detected fewer false-positive additional lesions than MRI.

The preliminary results of this research are promising, especially in demonstrating the ability of fluorine-18-labeled FDG to detect invasive breast cancer when used at low doses,” Freitas stated despite the fact that this imaging method has not yet been fully integrated into clinical practice.

As the first step towards becoming a part of the clinical practice in the future, this marks an important milestone in the development of this technology.”

There has been a disclosure that several authors of this study have ties to Radialis Medical; one of the authors holds a patent on solid-state tileable technology that targets organs.

Equipment was supplied by Radialis Medical and maintenance was provided by Radialis Medical.

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