Arkhom Termpittayapaisith said only yesterday, the fourth day of the seven-day road safety campaign, 81 died and 778 injured in 751 accidents.
Throughout the first four days, 280 died and 2,877 were injured, he said.
He said drunk driving and speeding continued to be the major causes of the accidents.
Sakhon Nakhon in the Northeast has the highest fatalities (7) while Chiang Mai recorded the highest number of accidents and injuries, at 33 and 35 respectively.
Motorcycles continued to be the most dangerous vehicle type and most accidents occurred on highways and roads in tambons. The time of day most prone to accidents was midnight to 4am, he added.