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Malaria Infection Can Be Reduced With New mRNA Vaccines



Malaria Infection Can Be Reduced With New mRNA Vaccines

(CTN News) – It has been reported that two new mRNA vaccines have been developed that may be able to reduce both malaria infection and transmission.

There was also a strong immune response induced by the vaccines regardless of whether they were administered individually or together, according to the researchers.

According to Nirbhay Kumar, a professor at the George Washington University Milken Institute School of Public Health, “Malaria elimination won’t happen overnight, but such vaccines could potentially banish malaria from many parts of the world in the near future,” said Kumar. This study was published on Thursday in the journal NPJ Vaccines in the journal Vaccines.

Kumar said in a statement, “MRNA vaccines have the potential to play a very substantial role in battling diseases like malaria.

We have observed the success of this technology in fighting COVID, so for this study we adapted it and used it to develop tools that could be used to attack malaria,” Kumar explained.

A report published in the journal Nature pointed out that the vaccine introduces a piece of messenger RNA. This is an RNA needed to produce a protein. This corresponds to a protein that is produced by the virus.

It is estimated that more than 90% of all malaria cases and 95% of all malaria deaths worldwide are due to the Anopheles mosquito. This is more specifically P. falciparum and P. vivax.

The majority of malaria deaths are seen in sub-Saharan Africa, but malaria is still a major threat to half of the world’s population.

Can you tell me how the Malaria study was conducted? 

As the researchers pointed out, there are two different ways in which mRNA vaccines work.

 The researchers immunized one group of mice with a mRNA vaccine that targets a protein that helps the parasites move through the body and invade the liver. This is done through infection of the liver.

As a result, other mice were also injected with a vaccine that targeted a protein that aids parasite reproduction within the midgut of mosquitoes.

As a result, these mice were then exposed to parasite-causing infections. As a result of the study, it was found that both vaccines induced a strong immune response in mice.

In addition, they were highly effective in reducing infection both in the host animal as well as in the mosquito vector.

It has been found that protection antibodies present during the transmission of parasites to healthy mosquitoes significantly reduce the parasite load in the mosquitoes, which is an important step in reducing malaria transmission, according to the researchers.

In addition to preventing infection, Kumar said these vaccines almost completely eliminated the potential for transmission of the infection.


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