HIV Model Does Not Expand Viral Reservoir After CD8+ T Cell Depletion



(CTN News) – It has been demonstrated that cytotoxic CD8+ T cells in the HIV Model reduce the lifespan of productively infected cells during acute simian immunodeficiency virus infection (a primate model of human immunodeficiency virus infection).

Despite this, they do not seem to be effective at preventing the establishment of a persistent reservoir of latently infected cells when long-term antiretroviral therapy is administered.

List of references

A. Robert Finzi, along with the other authors. In patients undergoing highly active antiretroviral therapy, a reservoir for HIV-1 has been identified. Science 278, 1295-1300 (1997) was published in Science.

Study showing the presence of quiescent CD4+ T lymphocytes carrying proviral DNA in people living with HIV and receiving antiretroviral therapy.

Whitney, J. B. et al. Rhesus monkeys were rapidly seeded with SIV virus prior to the development of viraemia from the virus. 512, 74-77 (2014) in Nature.

Research shows that reservoirs are seeded very rapidly after SIV infection of rhesus macaques and prior to the development of systemic viremia in the subjects.

A review of Evans, S. T., and Silvestri, G. Non-human primate models in AIDS research: a review. It’s current. An opinion.

The HIV AIDS journal, 8, 255-261 (2013). This review describes advances made in the use of animal models for HIV and AIDS research during the past few years.

There was an interesting paper published by Mc Brien, J. B. and Kumar, N. A. as well as Silvestri, G. Mechanisms of CD8+ T cell-mediated suppression of HIV/SIV replication by CD8+ T cells. The euro.

Journal of Immunology. In 2018, there will be 48, 898-914 days.

This review summarizes what CD8+ T cells do during natural HIV and SIV infection as well as the role they play when treated with ART.

N. R. Klatt et al. It has been shown that CD8+ lymphocytes are responsible for controlling viral replication in SIVmac239-infected rhesus macaques without reducing the lifespan of productively infected cells.

The PLoS Pathog journal. The journal PLOS ONE published this article on October 6, 2010.

The purpose of this study was to assess in vivo the effect of CD8 depletion on the lifespan of productively infected cells during chronic SIV infection of rhesus macaques infected with the virus.

Information additional to the above

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